The Chapel of El Salvador has an important Byzantine tower, whose construction was sponsored by Charles V´s secretary of State. The design is due to the architect Diego de Siloé and the execution and ornamentation to Andrés de Vandelvira, when Diego de Siloé died. The Sothern is the most interesting of its doors. Other important people who participated in the construction of this building were: Berruguete (main retable), esteban Janete (facade and sacristy), and Francisco de Villalpando (bars.)
The Chapel mixes in a harmonious way circles and rectangles, according to the humenistic style, covered by a vault in its head (funeral symbol). This building keeps the rests of "De los Cobos" family.