The Hospital de Santiago is also Vandelvira´s design, and has benne labelled "The Escorial of Andalucía" because of the Renaissance balance which presides over it. It was founded as a charity building by D. Diego de Los Cobos (who was brother of Juan Vázquez de Molina), and its construction was finished in 1575.

Originally, this Hospital was placed far away from the centre of the city, because it was built for people who was afected by the bubonic plague. However, this building had also other functions, such as chapel, funerary or residence of the bishop.